DEPARTMENT OF BIOCHEMISTRY
Address: 4, Nezavisimost Ave., Minsk, 220030, Belarus
Web page: http://bio.bsu.by/biohim/
Location: 10, Kurchatova str., Minsk, 4d floor.
The Department of Biochemistry is a modern, research-intensive division of faculty of biology. Since its foundation in 1964, the Department has developed an international reputation for excellence in research and teaching. For a brief history of the Department. click HERE.
Currently, Department has 32 full-time academic staff members and is over 200 undergraduate students are engaged in training. There are Animal Resource Center and 2 fully-equipped research laboratories on site: Laboratory of biochemistry of metabolism and Laboratory of applied problems of biochemistry.
The husbandry and veterinary care of all research animals are under the responsibility of Animal Resource Center. It is centrally managed by staff of trained animal caretakers and veterinarians. Animal facilities can accomodate multiple species of animals.
The Department offers a highly qualitied undergraduate curriculum on biochemistry with practical training, which exposes students to a wide range of modern experimental techniques. We provide a plethora of courses focusing on different special aspects of biochemistry. Our graduates hold faculty positions at outstanding academic institutions throughout the world or lead research teams in pharmaceutical or biotechnology industries.
The Department offers programs leading to M.Sc. and Ph.D. degrees. These research-intensive programs are complemented by courses on selected topics in biochemistry. Our Ph.D. graduates go on to successful post-doctoral fellowships and careers in research.
The Biochemistry Department provides many opportunities for undergraduate students to get involved in research. The research program allows students to participate in a faculty member's research project. In their 5th year, students can conduct a research project under the guidance of any of department members.
Biochemistry occupies a central place in science life and the research in the Department focuses on understanding the fundamental biochemical processes of biological systems, microbial, plant and animal. Department members have active research programs in signal transduction and regulation, molecular medicine, molecular cell biology and pathology, protein folding, biomolecular structure and function. The expertise and the research interests of Department members are used to integrate research with education.
The Department has modern research facilities for isolation of subcellular fractions; chromatographic separation and mass spectrometric identification of pharmaceuticals, xenobiotics, drug metabolites; chromatographic purification of products of biotechnology; spectrophotometric and fluorimetric analysis of enzyme activity; enzyme-linked immunoassay, two-dimensional gel electrophoresis, Western blot technique, as well as cell culture facilities.
Igor V. Semak, Head of Department of biochemistry
Mikhail M. Filimonau Associate professor
Nataliya M. Arol Associate professor
Tatiana A. Kukulianskaya Associate professor
Dzmitry A. Novikau Associate professor
Aksana I. Hubich Associate professor
Tatsiana N. Zyranava Senior lecturer
Marya P. Shapchits Associate professor
Elena O.Korik Associate professor
Sviatlana M. Piatrova Senior lecturer
Ana A. Bulatava Assistent
Maria S. Chumachenko Assistent
Kristina V. Pristupa Assistent
Uladzislau Harbavets Assistent
Darya I. Maksimovich Assistent
Svetlana M.Zjarskaja Head of research laboratory
Mikhail V. Sholukh Head of research laboratory
E.V.Bondaruk Junior research workers
E.V. Malushkova, A.V. Zhidetskiy, S.I. Brilevskaya, A.A. Chereshnev, A.V. Zharskaya Researchers.
T.J.Erastova, L.I.Bozhkova, M.V.Filich, V.M.Lavrova, L.I.Kuntsevich, E.A. Andreychenko, Y.S.Zhukovskaya, E. V. Trakhimchik Technicians.
- Biochemistry (associate professors N.M.Arol, T.A.Kukulianskaya).
- Biophysics (associate professors D.A.Novikau, M.M.Filimonau).
- Pharmaceutical Biotechnology (associate professor D.A.Novikau).
- Applied Biochemistry (associate professor D.A.Novikau).
- Radiobiology (associate professor M.M.Filimonau).
- Biotransformation of Substances (associate professor I.V.Semak).
- Enzyme Engineering (associate professor I.V.Semak).
- Isolation and purification of products of biotechnology (associate professor D.A.Novikau).
- Introduction in biochemistry as a profession. (associate professor O.I.Hubich).
- Enzymology (associate professor T.A.Kukulianskaya).
- Basics of toxicology (associate professor T.A.Kukulianskaya).
- Biochemistry of membranes (associate professor N.M.Arol).
- Basic Principles of Molecular Endocrinology (senior lecturer T.N.Zyranava).
- Enzyme Kinetics (associate professor I.V.Semak).
- Ecological Biochemistry (associate professor N.M.Arol).
- Bioenergetics (associate professor O.I.Hubich).
- Clinical Biochemistry (associate professor O.I.Hubich).
- Medical Biochemistry (associate professor O.I.Hubich).
- Basic Principles of Radiation Biochemistry (associate professor M.M.Filimonau).
- Bioinorganic Chemistry (senior lecturer S.M.Piatrova).
- Basic Principles of Neurochemistry (associate professor N.M.Arol).
- Biochemistry of Protein and Nucleic Acids (associate professor D.A.Novikau).
- Functional Biochemistry (senior lecturer T.N.Zyranava).
- Immunoenzyme Assay (associate professor I.V.Semak).
- Biochemistry of Vitamins (associate professor N.M.Arol).
- Biochemistry of Medicinal Plants (associate professor M.P.Shapchits)
- Evolutionary biochemistry (associate professor M.P.Shapchits)
- Molecular mechanisms of cytotoxic effects of xenobiotics; mechanisms of cell resistance to xenobiotics and physical environmental factors;
- Mechanisms of antioxidant/prooxidant action of natural compounds;
- Steroid and melatonin metabolism in various organs and tissues of mammals;
- Identification and structural analysis of bioactive substances and their metabolites by mass-spectrometry, gas- and high-performance liquid chromatography;
- Molecular mechanisms of liver diseases and their correction by natural compounds;
- Regulation of signal transduction by natural and synthetic prostaglandins;
- Generic drug bioavailability and bioequivalence.
Selected peer-reviewed publications
1. Muronetz, V.I., Sholukh M.V., Korpela T. // Use of Protein-Protein Interactions in Affinity Chromatography // Journal of Biochemical and Biophysical Methods. – 2001. - Vol. 49(1-3). - P. 29-47.
2. Semak I.V., Semak T.G., Ivanov A.I. Experimental cholestasis decreases concentration of the class alpha isoenzymes of glutathione S-transferase in rat liver cytosol. Medical Biochemistry - 2001. – Vol. 1. – P. 285-292.
3. Slominski A, Semak I, Pisarchik A, Sweatman T, Szczesniewski A, Wortsman J. Conversion of L-tryptophan to serotonin and melatonin in melanoma cells. FEBS Lett, 2002. Vol. 511. – P. 102-106.
4. Slominski A, Pisarchik A, Semak I, Sweatman T, Wortsman J, Szczesniewski A, Slugocki G, McNulty J, Kauser S, Tobin DJ. Serotoninergic and melatoninergic systems are fully expressed in human skin. FASEB J. 2002. - Vol. 16. – P. 896-898.
5. Slominski A, Pisarchik A, Semak I, Sweatman T, Szczesniewski A, Wortsman J. Serotoninergic system in hamster skin // J Invest Dermatol. 2002. Vol. 119, 934-942.
6. Slominski A, Pisarchik A, Johansson O, Jing C, Semak I, Slugocki G, Wortsman J, Tryptophan hydroxylase (TPH) expression in human skin cells // Biochim Biophys Acta. 2003. Vol. 1639, 80-86.
7. Slominski A, Pisarchik A, Semak I, Sweatman T, WortsmanJ Characterization of the serotoninergic system in C57BL/6 mouse skin // Eur J Biochem. 2003. Vol. 270, 3335-3344.
8. Semak I, Korik E, Naumova M, Wortsman J, Slominski A. Serotonin metabolism in rat skin: characterization by liquid chromatography – mass spectrometry // Arch Biochem Biophys, 2004. – Vol. 421. – P. 61-66.
9. Slominski A, Zjawiony J, Wortsman J, Semak I, Stewart J, Pisarchik A, Sweatman T, Marcos J, Dunbar C, C Tuckey R. A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin // Eur. J. Biochem, 2004. – Vol. 271 (21). – P. 4178-4188.
10. Shalova I.N., Asryants R.A., Sholukh M.V., Saso L., Kurganov B.I., Muronetz V.I., Izumrudov V.A.. Interaction of Polyanions with Basic Proteins, 2a Influence of Complexing Polyanions on the Thermoaggregation of Oligomeric Enzymes // Macromolecular Bioscience, 2005. – Vol. 5. – P. 1184-1192.
11. Slominski A, Fischer TW, Zmijewski MA, Wortsman J, Semak I, Zbytek B, Slominski RM, Tobin DJ. On the role of melatonin in skin physiology and pathology. Endocrine. 2005 – Vol. 27(2). – P.137-148. Review.
12. Slominski A, Semak I, Zjawiony J, Wortsman J, Li W, Szczesniewski A, Tuckey RC. The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism // FEBS J., 2005. – Vol. 272 (16). – P. 4080-4090.
13. Semak I, Korik E, Naumova M, Wortsman J, Slominski A. A novel metabolic pathway of melatonin: oxidation by cytochrome C // Biochemistry, 2005. – Vol. 44 (26). – P. 9300-9307.
14. Slominski A, Semak I, Zjawiony J, Wortsman J, Gandy MN, Li J, Zbytek B, Li W, Tuckey RC. Enzymatic metabolism of ergosterol by cytochrome P450scc to biologically active 17alpha,24-dihydroxyergosterol // Chem Biol., 2005. – Vol. 12 (8). – P. 931-939.
15. Senyuk O., Gorovoj L., Zhidkov A., Kovalyov V., Palamar L., Kurchenko V., Kurchenko N., Schroeder H.-Ch. Genome protection properties of the chitin-containing preparation Micoton // Advances in chitin science, 2005.— Vol. VIII.— Р. 430—434.
16. Slominski A, Zbytek B, Szczesniewski A, Semak I, Kaminski J, Sweatman T, Wortsman J. (2005) CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH // Am J Physiol Endocrinol Metab.; 288(4):E701-706.
17. Slominski A, Zbytek B, Semak I, Sweatman T, Wortsman J. CRH stimulates POMC activity and corticosterone production in dermal fibroblasts // J Neuroimmunol. 2005. – Vol. 162(1-2). – P. 97-102.
18. Cherviakovsky E.M., Bolibrukh D.A., Baranovsky A.V., Vlasova T.M., Kurchenko V.P., Gilep A.A., Usanov S.A. Oxidative modification of quercetin by hemeproteins // Biochem. Biophys. Res. Commun., 2006. - Vol. 342. – P.459–464.
19. Hubich A.I., Zheldakova T.A., Chernikhova T.V., Koroleva E.V., Lakhvich F.A., Sholukh M.V. Synthetic heteroprostanoids of A- and E-types as novel non-comprehensive inhibitors of adenylyl cyclase in rat hepatocytes // Biochem. Biophys. Res. Commun., 2006. – Vol. 341. – P. 357-362.
20. Slominski A, Semak I, Wortsman J, Zjawiony J, Li W, Zbytek B, Tuckey RC. An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2 // FEBS J., 2006. – Vol. 273 (13). –P. 2891-2901.
21. Hubich A. I., Sholukh M.V. Biochemistry of Prostaglandins of gruppe A // Biochemistry (Moscow), 2006. V. 71. N3. p. 229-238.
22. Fischer TW, Sweatman TW, Semak I, Sayre RM, Wortsman J, Slominski A. Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems // FASEB J., 2006. – Vol. 20 (9). – P. 1564-1566.
23. Tarun E.I, Kurchenko V.P., Metelitsa D.I. Flavonoids as effective protectors of urease againts ultrasonic inactivation in solutions // Bioorganic chemistry, 2006. V. 32. N4. p. 391-398.
24. Hubich A.I., Bondar A.Y., Kastsiuk T.U., Kastsiuk U.A., Lakhvich F.A., Sholukh M.V. Hepatoprotective action of prostaglandin A2 analogs under CCl4-induced liver injury in vitro // Hepatology Research, 2007. – Vol. 37. – P. 416-424.
25. Semak I, Korik E, Antonova M, Wortsman J, Slominski A. Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes. J Pineal Res. 2008 Nov;45(4):515-523.
26. Slominski AT, Zmijewski MA, Semak I, Sweatman T, Janjetovic Z, Li W, Zjawiony JK, Tuckey RC. Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. PLoS ONE. 2009;4(2):e4309.
27. Zavatski S., Khinevich N., Girel K., Redko S., Kovalchuk N., Komissarov I., Lukashevich V., Semak I., Mamatkulov K., Vorobyeva M., Arzumanyan G., Bandarenka H. Surface Enhanced Raman Spectroscopy of Lactoferrin Adsorbed on Silvered Porous Silicon Covered with Graphene. Biosensors 2019, 9(1), 34; https://doi.org/10.3390/bios9010034.
28. Zakharova ET, Sokolov AV, Pavlichenko NN, Kostevich VA, Abdurasulova IN, Chechushkov AV, Voynova IV, Elizarova AY, Kolmakov NN, Bass MG, Semak IV, Budevich AI, Kozhin PM, Zenkov NK, Klimenko VM, Kirik OV, Korzhevskii DE, Menshchikova EB, Vasilyev VB. Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin. Biometals. 2018 May 10. doi: 10.1007/s10534-018-0111-9.
29. Slominski AT, Semak I, Fischer TW, Kim TK, Kleszczyński K, Hardeland R, Reiter RJ. Metabolism of melatonin in the skin: Why is it important? Exp Dermatol. 2017 Jul;26(7):563-568.
30. Slominski AT, Zmijewski MA, Semak I, Kim TK, Janjetovic Z, Slominski RM, Zmijewski JW. Melatonin, mitochondria, and the skin. Cell Mol Life Sci. 2017 Nov;74(21):3913-3925.
31. Chekhun VF, Zalutskii IV, Naleskina LA, Lukianova NY, Yalovenko TM, Borikun TV, Sobchenko SO, Semak IV, Lukashevich VS. Modifying effects of lactoferrin in vitro on molecular phenotype of human breast cancer cells. Exp Oncol. 2015 Sep;37(3):181-186.
32. Slominski AT, Li W, Kim TK, Semak I, Wang J, Zjawiony JK, Tuckey RC. Novel activities of CYP11A1 and their potential physiological significance.
J Steroid Biochem Mol Biol. J Steroid Biochem Mol Biol. 2015 Jul;151:25-37. Review.
33. Slominski AT, Kleszczyński K, Semak I, Janjetovic Z, Zmijewski MA, Kim TK, Slominski RM, Reiter RJ, Fischer TW.
Local Melatoninergic System as the Protector of Skin Integrity. Int J Mol Sci. 2014 Sep 30;15(10):17705-17732. Review
34. Slominski AT, Kim TK, Shehabi HZ, Tang EK, Benson HA, Semak I, Lin Z, Yates CR, Wang J, Li W, Tuckey RC.
In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. Mol Cell Endocrinol. 2014 Mar5;383(1-2):181-192.
35. Slominski AT, Zmijewski MA, Semak I, Zbytek B, Pisarchik A, Li W, Zjawiony J, Tuckey RC.
Cytochromes p450 and skin cancer: role of local endocrine pathways. Anticancer Agents Med Chem. 2014 Jan;14(1):77-96. Review.
36. Slominski A, Kim TK, Zmijewski MA, Janjetovic Z, Li W, Chen J, Kusniatsova EI, Semak I, Postlethwaite A, Miller DD, Zjawiony JK, Tuckey RC.
Novel vitamin D photoproducts and their precursors in the skin. Dermatoendocrinol. 2013 Jan 1;5(1):7-19. Review.
37. Slominski AT, Kim TK, Shehabi HZ, Semak I, Tang EK, Nguyen MN, Benson HA, Korik E, Janjetovic Z, Chen J, Yates CR, Postlethwaite A, Li W, Tuckey RC.
In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1. FASEB J. 2012;26(9):3901-3915.
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