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Биологический факультет БГУ - Кафедра биохимии.    

Department of Biochemistry.


Igor V. Semak


Igor V. Semak


Address: Department of biochemistry, Belarusian State University, Nezavisimosti Ave., 4, Minsk, 220030, Belarus

Phone: +375 (17) 209 58 56; 209 59 14
Fax: +375(17) 209 58 56

E-mail: semakbsu.by


Education:

Ph.D. in Biochemistry

Positions held:

Head of Department of biochemistry

Teaching experience:

Biotransformation of Substances;
Enzyme Engineering;
Enzyme Kinetics;
Enzyme Immunoassay.

Research interest:

- Molecular mechanisms of cytotoxic effects of xenobiotics; mechanisms of cell resistance to xenobiotics and physical environmental factors;
- Mechanisms of antioxidant/prooxidant action of natural compounds;
- Steroid and melatonin metabolism in various organs and tissues of mammals;
- Identification and structural analysis of bioactive substances and their metabolites by mass-spectrometry, gas- and high-performance liquid chromatography;
- Molecular mechanisms of liver diseases and their correction by natural compounds;
- Generic drug bioavailability and bioequivalence;
- Isolation and physicochemical properties of recombinant human lactoferrin from milk of transgenic goats.

Selected peer-reviewed publications

1. Semak I.V., Semak T.G., Ivanov A.I. Experimental cholestasis decreases concentration of the class alpha isoenzymes of glutathione S-transferase in rat liver cytosol. Medical Biochemistry - 2001. – Vol. 1. – P. 285-292.

2. Slominski A, Semak I, Pisarchik A, Sweatman T, Szczesniewski A, Wortsman J. Conversion of L-tryptophan to serotonin and melatonin in melanoma cells. FEBS Lett, 2002. Vol. 511. – P. 102-106.

3. Slominski A, Pisarchik A, Semak I, Sweatman T, Wortsman J, Szczesniewski A, Slugocki G, McNulty J, Kauser S, Tobin DJ. Serotoninergic and melatoninergic systems are fully expressed in human skin. FASEB J. 2002. - Vol. 16. – P. 896-898.

4. Slominski A, Pisarchik A, Semak I, Sweatman T, Szczesniewski A, Wortsman J. Serotoninergic system in hamster skin // J Invest Dermatol. 2002. Vol. 119, 934-942.

5. Slominski A, Pisarchik A, Johansson O, Jing C, Semak I, Slugocki G, Wortsman J, Tryptophan hydroxylase (TPH) expression in human skin cells // Biochim Biophys Acta. 2003. Vol. 1639, 80-86.

6. Slominski A, Pisarchik A, Semak I, Sweatman T, WortsmanJ Characterization of the serotoninergic system in C57BL/6 mouse skin // Eur J Biochem. 2003. Vol. 270, 3335-3344.

7. Semak I, Korik E, Naumova M, Wortsman J, Slominski A. Serotonin metabolism in rat skin: characterization by liquid chromatography – mass spectrometry // Arch Biochem Biophys, 2004. – Vol. 421. – P. 61-66.

8. Slominski A, Zjawiony J, Wortsman J, Semak I, Stewart J, Pisarchik A, Sweatman T, Marcos J, Dunbar C, C Tuckey R. A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin // Eur. J. Biochem, 2004. – Vol. 271 (21). – P. 4178-4188.

9. Slominski A, Fischer TW, Zmijewski MA, Wortsman J, Semak I, Zbytek B, Slominski RM, Tobin DJ. On the role of melatonin in skin physiology and pathology. Endocrine. 2005 – Vol. 27(2). – P.137-148. Review.

10. Slominski A, Semak I, Zjawiony J, Wortsman J, Li W, Szczesniewski A, Tuckey RC. The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism // FEBS J., 2005. – Vol. 272 (16). – P. 4080-4090.

11. Semak I, Korik E, Naumova M, Wortsman J, Slominski A. A novel metabolic pathway of melatonin: oxidation by cytochrome C // Biochemistry, 2005. – Vol. 44 (26). – P. 9300-9307.

12. Slominski A, Semak I, Zjawiony J, Wortsman J, Gandy MN, Li J, Zbytek B, Li W, Tuckey RC. Enzymatic metabolism of ergosterol by cytochrome P450scc to biologically active 17alpha,24-dihydroxyergosterol // Chem Biol., 2005. – Vol. 12 (8). – P. 931-939.

13. Slominski A, Zbytek B, Szczesniewski A, Semak I, Kaminski J, Sweatman T, Wortsman J. (2005) CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH // Am J Physiol Endocrinol Metab.; 288(4):E701-706.

14. Slominski A, Zbytek B, Semak I, Sweatman T, Wortsman J. CRH stimulates POMC activity and corticosterone production in dermal fibroblasts // J Neuroimmunol. 2005. – Vol. 162(1-2). – P. 97-102.

15. Slominski A, Semak I, Wortsman J, Zjawiony J, Li W, Zbytek B, Tuckey RC. An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2 // FEBS J., 2006. – Vol. 273 (13). –P. 2891-2901.

16. Fischer TW, Sweatman TW, Semak I, Sayre RM, Wortsman J, Slominski A. Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems // FASEB J., 2006. – Vol. 20 (9). – P. 1564-1566.

17. Semak I, Korik E, Antonova M, Wortsman J, Slominski A. Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes // J Pineal Res. 2008; Vol. 45(4). P.515-523.

18. Slominski AT, Zmijewski MA, Semak I, Sweatman T, Janjetovic Z, Li W, Zjawiony JK, Tuckey RC. Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin // PLoS ONE. 2009;4(2):e4309.

19. Semak I.V., Alekseev N.A., Korik E.O., Drobyshevskii A.M., Antonova M.V. Determination of roxythromycin in blood serum by liquid chromatography with mass spectrometric detection // Journal of Analytical Chemistry. 2011; Vol. 66(2). P.194-200.

20. Zavatski S., Khinevich N., Girel K., Redko S., Kovalchuk N., Komissarov I., Lukashevich V., Semak I., Mamatkulov K., Vorobyeva M., Arzumanyan G., Bandarenka H. Surface Enhanced Raman Spectroscopy of Lactoferrin Adsorbed on Silvered Porous Silicon Covered with Graphene. Biosensors 2019, 9(1), 34; https://doi.org/10.3390/bios9010034.

21. Zakharova ET, Sokolov AV, Pavlichenko NN, Kostevich VA, Abdurasulova IN, Chechushkov AV, Voynova IV, Elizarova AY, Kolmakov NN, Bass MG, Semak IV, Budevich AI, Kozhin PM, Zenkov NK, Klimenko VM, Kirik OV, Korzhevskii DE, Menshchikova EB, Vasilyev VB. Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin. Biometals. 2018 May 10. doi: 10.1007/s10534-018-0111-9.

22. Slominski AT, Semak I, Fischer TW, Kim TK, Kleszczyński K, Hardeland R, Reiter RJ. Metabolism of melatonin in the skin: Why is it important? Exp Dermatol. 2017 Jul;26(7):563-568.

23. Slominski AT, Zmijewski MA, Semak I, Kim TK, Janjetovic Z, Slominski RM, Zmijewski JW. Melatonin, mitochondria, and the skin. Cell Mol Life Sci. 2017 Nov;74(21):3913-3925.

24. Chekhun VF, Zalutskii IV, Naleskina LA, Lukianova NY, Yalovenko TM, Borikun TV, Sobchenko SO, Semak IV, Lukashevich VS. Modifying effects of lactoferrin in vitro on molecular phenotype of human breast cancer cells. Exp Oncol. 2015 Sep;37(3):181-186.

25. Slominski AT, Li W, Kim TK, Semak I, Wang J, Zjawiony JK, Tuckey RC. Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol. J Steroid Biochem Mol Biol. 2015 Jul;151:25-37.

26. Slominski AT, Kleszczyński K, Semak I, Janjetovic Z, Zmijewski MA, Kim TK, Slominski RM, Reiter RJ, Fischer TW. Local Melatoninergic System as the Protector of Skin Integrity. Int J Mol Sci. 2014 Sep 30;15(10):17705-17732.

27. Slominski AT, Kim TK, Shehabi HZ, Tang EK, Benson HA, Semak I, Lin Z, Yates CR, Wang J, Li W, Tuckey RC. In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. Mol Cell Endocrinol. 2014 Mar5;383(1-2):181-192.

28. Slominski AT, Zmijewski MA, Semak I, Zbytek B, Pisarchik A, Li W, Zjawiony J, Tuckey RC. Cytochromes p450 and skin cancer: role of local endocrine pathways. Anticancer Agents Med Chem. 2014 Jan;14(1):77-96.

29. Slominski A, Kim TK, Zmijewski MA, Janjetovic Z, Li W, Chen J, Kusniatsova EI, Semak I, Postlethwaite A, Miller DD, Zjawiony JK, Tuckey RC. Novel vitamin D photoproducts and their precursors in the skin. Dermatoendocrinol. 2013 Jan 1;5(1):7-19.

30. Slominski AT, Kim TK, Shehabi HZ, Semak I, Tang EK, Nguyen MN, Benson HA, Korik E, Janjetovic Z, Chen J, Yates CR, Postlethwaite A, Li W, Tuckey RC. In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1. FASEB J. 2012;26(9):3901-3915.



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