DEPARTMENT OF MICROBIOLOGY
Address: 4, Nezavisimost Ave., Minsk, 220030, Belarus
web page: http://bio.bsu.by/microbio/
Location: 10, Kurchatova str., Minsk, 3d floor.
The department was established in 1960. During this time it was headed by Prof. B. Ya. Elbert (1960–1963), Prof. P. A. Bulanov (1964–1969) and Prof. Yu. K. Fomichev (1969–1988). Prof. V. A. Prokulevich has been the Head of the Department since 1988.
Prof. Dr. V. A. Prokulevich − Head of Department, Prof. Dr. Yu. K. Fomichev, Prof. Dr. M. A. Titok;
Associate professors: V. V. Lysak, R. A. Zheldakova, V. E. Miamin, A. G. Pesnyakevich and O. V. Fomina
Assistant: E. I. Ignatenko
Scientists: N. N. Nashkevich, R. I. Astapovich, M. I. Potapovich, S. G. Golenchenko.
Technicians: O. A. Vygovskaya, S. V. Patyupina, T. A. Rachkovskaya, A. D. Bondarenko.
The department carries out training in the following areas: "Biology, specialization "microbiology", "Biotechnology" "Bioecology”.
List of disciplines, assigned to be studied at the Department of Microbiology:
Main courses of studies:
3. Fundamentals of Immunology
4. Fundamentals of Biotechnology
5. Molecular Biology of Cancer
6. Vector Systems
7. Cell Cultivation
8. Decomposers in Natural and Artificial Ecosystems
9. Cellular Engineering
10. Biotechnology of Industrial Waste Utilisation
1. Molecular Bacteriology.
2. The Most Important Groups of Prokaryotic Microorganisms.
3. Molecular Mechanisms of Genetic Processes.
4. Extrachromosomal Hereditary Structures of Microbial Cells.
5. Mechanisms of Antibiotic Biosynthesis and Their Effect on Bacterial Cells
6. Applied Aspects of Immunology
7. Industrial Microbiology
8. Medical and Sanitary Microbiology
9. Phytopathogenic Microorganisms.
10. Regulation of Metabolic Processes in Bacteria.
11. Fundamentals of Molecular Biology.
13. The Most Important Groups of Microorganisms.
14. Biotechnology - Principles and Applications
Main research directions
· Development of biological preparations for the prevention and treatment of diseases of farm animals.
· Studying the genetic regulation of biosynthesis of biologically active compounds by bacterial cells.
· Creating strains-producers for the biotechnology industry.
· Investigation of pathogenic bacteria of the genus Erwinia to obtain information about the functional activity of several gene products important for the interaction with the host plants.
· Isolation, identification and study of spreading of bacterial pathogens of vegetable crops in Belarus. Development of molecular methods of plant pathogen identification.
· Studies of antimicrobial activities of certain original synthetised organic compounds and possibilities of their practical application.
The group of genetic engineering of veterinary preparations led by prof. V.A. Prokulevich is currently working on:
· cloning of the genes and expressing proteins of alpha interferons of agricultural animals, studying of their specificity as well as antiviral, immune modulating and anti-proliferation activity with the final aim of creation of highly effective preparations for veterinary;
· development and creation of the biologically active cytokine preparation components and antibiotics of prolonged action;
· creation of solvents for increasing the effectiveness of vaccines used in veterinary;
· development of new generation of disinfectants.
These research activities are funded by the State Programmes “Industrial Biotechnology” and “New Technologies and Biological Preparations for Agriculture, Industry, Medicine and Environment Protection”.
The department is also constantly developing on a permanent basis the new approaches in teaching microbiology, biotechnology and related disciplines. Its activities include the development and publication of textbooks, manuals, recommendations, guidelines for the laboratory classes for students undergoing the training and expertise within the department as well as constant development and improvement of new methods of students’, self-control taking into account the directions of development of higher education in Belarus.
Teaching aids developed by members of the department in recent years:
1. V.V. Grichik, A.G. Pesnyakevich, I.V. Bogacheva, O.N. Rogozhnikov, V.V. Lysak. Common biology. Experimental textbook for 11th grade of secondary schools / Minsk: Narodnaya Asveta, 2004, 135 p. (in Russian)
2. Blazhevich O.V. Cell Cultivation: Lecture course / Minsk: BSU, 2005. 78 p. (in Russian)
3. R. A. Zheldakova. Mechanisms of Antibiotic Biosynthesis and Their Effect on Bacterial Cells: Teaching aids / Minsk: BSU, 2005. 123 p. (in Russian)
4. A.E. Korenkov, N.V. Korenkova, A. G. Pesnyakevich. Ecology Olympiads: preparation and performance / Minsk: Rodiola-plus, 2005. 212 p. (in Russian)
5. R. A. Zheldakova, V.E. Myamin. Phytopathogenic Microorganisms : Teaching aids / Minsk: BSU, 2006. 116 p. (in Russian)
6. Yu. K. Fomichev, A.N. Evtushenkov. Introduction to Biotechnology. Lecture course / Minsk: BSU, 2005. 78 p. (in Russian)
7. A. G. Pesnyakevich Fundamentals of Immunology: Курс лекций / Minsk: BSU, 2008. 195 с. (in Russian)
8. V. V. Lysak. Microbiology: Textbook / Minsk: BSU, 2007. 343 p. (in Russian)
9. R. A. Zheldakova, V.D. Poliksenova, V. V. Lysak. Methodological approaches to organization of controlled independent work of students within the faculty of biology of the BSU // Proc. Resp. Conf. “Informational-methodological supplies for the controlled independent work of university students”. Minsk: BSU, 2007. P. 162-166. (in Russian)
Recent scientific publications
1. V. E. Myamin, A. G. Pesnyakevich, V. A. Prokulevich. Purification of pectine metabolites // Vestnik BSU. Ser. 2. 2003. № 1. P.47–51. (in Russian)
2. S.A. Skoblyakov, V. E. Myamin, A.L. Lagonenko, A. G. Pesnyakevich, Y.A. Nikolaichik. The effect of the pelW and kdgR mutations on pectinases production by Erwinia carotovora subsp. atroseptica // Vestnik BSU. Ser. 2. 2004. № 2. P.40–44. (in Russian)
3. V. E. Myamin, A. G. Pesnyakevich, Y.A. Nikolaichik, V. A. Prokulevich. Genetic regulation of the pathogenicity and virulence factors in Erwinia carotovora subsp. atroseptica. Identification of the kduD gene // Genetics. 2004. Т. 40. № 9. P. 1187–1193. (in Russian)
4. V. E. Myamin, A. G. Pesnyakevich, V. A. Prokulevich Genetic regulation of the pathogenicity and virulence factors in Erwinia carotovora subsp. atroseptica. Phenotypic characterization of the kduD mutant bacteria // Genetics. 2004. Т. 40. № 9. P.1194–1199. (in Russian)
5. A.V. Lagodich, E.A. Cherva, Ya.V. Shtanyuk, V. A. Prokulevich, Yu. K. Fomichev, A.A. Prosorov, M.A. Titok. Construction of the vector system for molecular cloning in the cells of Bаcillus subtilis and Escherichia coli // Mol. Biol. 2005. Т. 39. №2. P.345–348 (in Russian)
6. M.A. Titok, V. A. Prokulevich, L. Janniere. The influence of the host cell replication machinery on the inheritance of the pBS72 plasmid of Bacillus subtilis // Proc. NAS Belarus. 2005. Т.49. №3. P.70–76. (in Russian)
7. Zheldakova R. A., Lysak V. V., Mitroshkina O. A. Creation a culture collection of microorganisms for education purposes // Microbial diversity: current situation, conservation strategy and biotechnological potentialites: Proceedings of II Int. Conf., 20–25 September, 2005, Perm/Institute of Ecology and Genetics of Micro-organisms, Ural Branch, Russian Academy of Sciences. 2005. P. 216.
8. R. A. Zheldakova, A. G. Pesnyakevich, V. V. Lysak. 30 years of studying bacteria from the genus Erwinia: results and perspectives // Vestnik BSU. Ser. 2. 2006. № 3. P.65–68. (in Russian)
9. Loginova N. V., Kovalchuk T. V., Zheldakova R. A., Polozov H. Il, Sorokin V. L., Shadyro O. I. Copper (II) complexes of sterically hindered diphenol derivates: synthesis, characterization and microbiological studies // Centr. Eur. J. Chem. — 2006/ — V. 4, №3. — P. 440-457.
10. Loginova N. V., Kovalchuk T. V., Zheldakova R. A., Polozov H. I., Sorokin V. L., Shadyro O. I. Synthesis, characterization antifungal activity of copper (II) complexes of sterically hinded diphenol derivates // Polyhedron. — 2006. — Vol. 25. — P. 3603-3610.
11. Loginova N. V., Kovalchuk T. V., Zheldakova R. A., Polozov H. I., Sorokin V. L., Shadyro O. I. Synthesis and biological evaluation of copper (II) complexes of sterically hinded o-aminophenol derivates as antimicrobial agents // Bioorg. Med. Chem. Lett. — 2006. — Vol. 16. — P. 5403-5407.
12. Loginova N. V., Polozov H. I, Sorokin V. L., Shadyro O. I., R. A. Zheldakova Bioactive metallocomplexes of sterically shielded diphenol and aminophenol derivatives as the new direction for development of antimicrobial and antiviral preparations // Vestnik BSU. Ser. 2. — 2006. — №3. — P. 3-20. (in Russian)
13. Yu.V. Seleznyova, V. A. Prokulevich Development of veterinary preparations on the basis of genetically engineered strains producing unspecific immune modulators and compounds with antioxidant activity // Molecular applied genetics: scientific works. Research results within the state programme “Genetic engineereing” 2002-2006. — 2006. — Т. 3. — P. 115-119. (in Russian)
14. Potapenko N.T., Loginova N.V., R. A. Zheldakova, G.P. Shevchenko. Ag-SiO2 nanostructures with antimicrobial activity // Vestnik BSU. Ser. 2. — 2008. — №1. — P. 18-22. (in Russian)
15. S.V. Smolskaya, A.G. Pesnyakevich. Mechanisms of the intercellular interactions in prokaryotes // Proceedings of the Belarusian State University. Vol. 1, 2006, P. 42-55. (in Russian)
16. S. A. Skoblyakov, V. E. Myamin, A. G. Pesnyakevich. Creation of the genetic constructs for the inactivation of the Eca0852 and Eca0804 genes of Erwinia carotovora subsp. atroseptica // Proceedings of the Belarusian State University. Vol. 2, 2007. P. 172-180. (in Russian)
17. 21. M.I. Potapovich, V. A. Prokulevich. Characterisation of the chicken α-interferon and influence of the gene structure on its expression in the cells of Escherichia coli // Vestnik BSU. Ser. 2, 2008. №2. – P. 34-37 (in Russian)
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