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Биологический факультет БГУ - Кафедра генетики.    

Department of Genetics


Vasily V. Grinev


Candidate of Sciences in Biology, Associate Professor,

Scientific Head of the Sector of Human Molecular Genetics.








News | Curriculum Vitae | Educational work | Research | Publications | Software | Presentations | Contacts

 

Books/Contributions to books.

1) Glushen S. V., Kunickaia M. P., Grinev V. V., Veremeenko E. G., Kozhuro Yu. I. Cytology and Histology. A brief atlas: A teaching toolkit. // Belarusian State University Press, Minsk, 2017. 75 pp.

2) Maximova N. P., Titok M. A., Anoxina V. S., Khramcova E. A., Grinev V. V., Kunickaia M. P. Problems book in Genetics. // Belarusian State University Press, Minsk, 2008. 167 pp.

3) Grinev V. V. Human molecular genetics. // Belarusian State University Press, Minsk, 2006. 130 pp.

4) Grinev V. V. Kinetic analysis of conjugation between effector and target cells by flow cytometry. // In book: Flow cytometry methods in medical and biological researches, Ed. by M. P. Potapnev. SE RSML Press, Minsk, 2003. P. 81-88.

 

Manuals and guides.

1) Glushen S. V., Grinev V. V., Kunickaia M. P. Cytology and Histology. The methodical guide to the student’s laboratorial works. // Belarusian State University Press, Minsk, 2017. 22 pp.

2) Grinev V. V., Romanouskaya T. V., Kirsanava A. D., Ilyushonak I. M., Migas A. A., Aleinikova O. A. Methodological approaches to analysis of the fusion oncogene AML1-ETO expression in human leukemia cells. // Belarusian State University Press, Minsk, 2015. 71 pp.

3) Grinev V. V., Posrednik D. V., Sevyaryn I. N., Potapnev M. P. Gene modification of human cells by lentiviral transduction in vitro and ex vivo. Laboratory manual. // Belarusian State University Press, Minsk, 2010. 82 pp.

4) Glushen S. V., Romanouskaya T. V., Grinev V. V. System approach in assessment of programmed cell death (apoptosis) of human cells. Laboratory manual. // Belarusian State University Press, Minsk, 2009. 43 pp.

5) Grinev V. V. Introduction into technology of polymerase chain reaction. Laboratory manual. // Belarusian State University Press, Minsk, 2008. 48 pp.

6) Grinev V. V. Introduction into technology of RNA interference. Laboratory manual. // Belarusian State University Press, Minsk, 2008. 40 pp.

7) Glushen S. V., Grinev V. V., Kunickaia M. P., Titok M. A. Cytology and Histology. The methodical guide to the student’s laboratorial works. // Belarusian State University Press, Minsk, 2004. 22 pp.

8) Titok M. A., Grinev V. V. Genetics: In the 6 of parts. Part 4: Gene interactions. The educational and methodical guide. // Belarusian State University Press, Minsk, 2003. 30 pp.

9) Titok M. A., Grinev V. V. Genetics: In the 6 of parts. Part 5: Linkage and crossing-over. The educational and methodical guide. // Belarusian State University Press, Minsk, 2003. 19 pp.

10) Titok M. A., Grinev V. V. Genetics: In the 6 of parts. Part 6: Physical and genetic mapping. The educational and methodical guide. // Belarusian State University Press, Minsk, 2003. 22 pp.

11) Potapnev M. P., Buglova S. E., Chernovetsky M. A., Martsev S. P., Kravchuk Z. I., Petyovka N. V., Grinev V. V., Belevtsev M. V., Migal N. V. Laboratorial guide for measure of humoral immunity in children with acute leukemias. // BRPCCOH Press, Minsk, 2001. 24 pp.

 

Articles in journals.

1) Volkov A. V., Yatskou M. M., Grinev V. V. A study of the feature selection algorithm impact on exon classification. // Journal of the Belarusian State University. Mathematics and Informatics. – 2018.

2) Grinev V. V. Retention of introns in the transcriptome of leukemic and normal human blood cells. // Molecular and Applied Genetics. – 2018. – Vol. 25. – P. 45-55.

3) Grinev V. V., Heidenreich O. The knockdown of the fusion oncogene KMT2A-AFF1 is associated with differential RNA splicing in human acute lymphoblastic leukemia cells. // Journal of the Belarusian State University. Biology. – 2017. – № 3. – P. 21-27.

4) Saurytskaya H. A., Ilyushonak I. M., Grinev V. V. Development of the lentiviral vector with GC-rich segment of the promoter region of fusion oncogene RUNX-RUNX1T1. // Journal of the Belarusian State University. Biology. – 2017. – № 3. – P. 28-34.

5) Ilyushonak I. M., Gunko E. P., Antonovich M. L., Yatskou M. M., Kustanovich A. M., Sukhareuski A. Y., Skakun V. V., Grinev V. V. Study of RNA splicing patterns of the human RUNX1-RUNX1T1 fusion oncogene by the methods of data mining and next-generation sequencing. // Molecular and Applied Genetics. – 2017. – Vol. 23. – P. 92-101.

6) Ramanouskaya T. V., Grinev V. V. The determinants of alternative RNA splicing in human cells. // Molecular Genetics and Genomics. – 2017. – Vol. 292. – P. 1175-1195.

7) Ilyushonak I. M., Saurytskaya H. A., Yatskov N. N., Skakun V. V., Grinev V. V. Extending the "two-hits" hypothesis: the molecular mechanisms of RUNX1-RUNX1T1-mediated leukemogenesis. // Journal of the `Belarusian State University. Biology. – 2017. – №. 2. – P. 3-16.

8) Grinev V. V., Kushal D. I., Charapovich V. S. CelNetAnalyzer: high-performance Java package for the topological analysis of cellular networks. // Journal of Bioinformatics and Genomics. – 2017. – № 1. – P. 1-8.

9) Maximova N. P., Grinev V. V., Feklistova I. N., Anohina V. S., Lysak V. V., Ramanouskaya T. V., Khramtsova E. A., Veremeenko E. G., Sauk I. B., Ilyushonak I. N., Melnikava A. A., Romanchuk I. Y., Semashko A. I. Theoretical and applied aspects of using of molecular and cellular technologies in research of genes and genomes of microorganisms, plants and humans. // Bulletin of the Belarusian State University. Seria 2. Chemistry. Biology. Geography. – 2016. – № 3. – P. 79-91.

10) Grinev V. V., Migas A. A., Kirsanava A. D., Mishkova O. A., Siomava N., Ramanouskaya T. V., Vaitsiankova A. V., Ilyushonak I. M., Nazarov P. V., Vallar L., Aleinikova O. V. Decoding of exon splicing patterns in the human RUNX1-RUNX1T1 fusion gene. // The International Journal of Biochemistry and Cell Biology. – 2015. – Vol. 68. – P. 48-58.

11) Migas A. A., Mishkova O. A., Ramanouskaya T. V., Ilyushonak I. M., Aleinikova O. V., Grinev V. V. RUNX1T1/MTG8/ETO gene expression status in human t(8;21)(q22;q22)-positive acute myeloid leukemia cells. // Leukemia Research. – 2014. – Vol. 38. – P. 1102-1110.

12) Grinev V. V., Ramanouskaya T. V., Gloushen S. V. Multidimensional control of cell structural robustness. // Cell Biology International. – 2013. – Vol. 37. – P. 1023-1037.

13) Grinev V. V. Design and quality control of short interfering RNAs. // Molecular Biology. – 2012. – Vol. 46, № 6. – P. 739-754.

14) Grinev V. V., Posrednik D. V. Mapping of the 3’-end for artificial human microRNAs. // Russian Journal of Genetics. – 2012. – Vol. 48, № 7. – P. 759-761.

15) Grinev V. V., Seviaryn I. N., Posrednik D. V., Kosmacheva S. M., Potapnev M. P. Highly efficient transfer and stable expression of two genes upon lentivirus transduction of mesenchymal stem cells from human bone marrow. // Russian Journal of Genetics. – 2012. – Vol. 48, № 3. – P. 336-346.

16) Grinev V. V., Shchablykina N. Y., Posrednik D. V., Ramanouskaya T. V. Does RUNX1-ETO fusion gene really need in cooperation with other mutated genes for leukemia transformation of hematopoietic cells? // Blood. – 2012. – Vol. 119, № 6. – E-Letters.

17) Grinev V. V., Posrednik D. V., Heidenreich O. Effective and specific control of AML1/ETO gene expression in acute myeloid leukemia cells by lentivector-based RNA-interference. // Molecular Biology. – 2011. – Vol. 45, № 2. – P. 300-308.

18) Ponthan F., McNeill H., Buechler L., Grinev V., Vormoor J., Heidenreich O. Significance of fusion genes for maintenance of leukaemia. // Blood. – 2011. – Vol. 118. – P. 1053-1054.

19) Posrednik D. V., Ramanouskaya T. V., Radzisheuskaya A. A., Khatskevich А. А., Goncharevich A. Y., Cherepovich V. S., Grinev V. V. Structural and thermodynamic features of intergenic and intronic human primary microRNAs. // Molecular Biology. – 2011. – Vol. 45, № 3. – P. 508-516.

20) Romanouskaya T. V., Grinev V. V. Cytotoxic effect of flavonoids on leukemia cells and normal cells of human blood. // Bulletin of Experimental Biology and Medicine. – 2009. – Vol. 148, № 1. – P. 57-59.

21) Ramanouskaya T. V., Smolnykova V. V., Grinev V. V. Relationship between structure and antiproliferative, proapoptotic and differentiation effect of flavonoids on chronic myeloid leukemia cells // Anticancer Drugs. – 2009. – Vol. 20, № 7. – P. 573-583.

22) Shakhbazau A. V., Sevyaryn I. N., Goncharova N. V., Grinev V. V., Kosmacheva S. M., Potapnev M. P. Viral vectors for stable transduction of human mesenchymal stem cells: systems based on adeno-associated viruses and lentiviruses // Bulletin of Experimental Biology and Medicine. – 2008. – Vol. 146, № 4. – P. 531-533.

23) Potapnev M. P., Belevtsev M. V., Bortkevich L. G., Grinev V. V., Martsev S. P., Kravchuk Z. I., Migal N. V., Aleinikova O. V. Significance of serum immunoglobulin G for leukocytosis and prognosis in childhood B-lineage acute lymphoblastic leukemia. // Pediatric Blood and Cancer. – 2004. – Vol. 42, № 5. – P. 421-426.

24) Grinev V. V., Grigorovich S. A., Shman T. V., Sheleg S. V., Smolnikova V. V., Potapnev M. P., Svirnovski A. I. Different mechanisms of resistance to lymphokine-activated killer (LAK) cells in leukemic cell sublines selected by etoposide or by LAK cells. // Hematology. – 2001. – Vol. 6, № 5. – P. 321-329.

25) Grinev V. V., Smolnykova V. V., Moroz J. A., Potapnev M. P. Markers of in vitro induced resistance of B-lymphoblastoid cell line IM-9 to lysis by lymphokine-activated killer (LAK) cells. // Experimental Oncology. – 2001. – Vol. 23, № 3. – P. 197-203.

26) Grinev V. V., Grigorovich S. A., Potapnev M. P. Differential expression of LFA-1 due to drug or immune selection in vitro of B-lymphoblastoid cell line IM-9. // Immunology Letters. – 2000. – Vol. 73, № 2-3 (Special Issue). – P. 124.

27) Kuzmenok O. I., Grinev V. V., Ponomareva E. N., Smolnykova V. V. T cell- and antibody-mediated disorders in myasthenia gravis patients from Belarus. // Journal of Leukocyte Biology. – 1997. – Supplement. – P. 20.

 

Conference proceedings.

1) Volkov A. V., Yatskou M. M., Grinev V. V. Classification of exons of human genes using algorithms for automatic selection of exon attributes. // Proceedings of the First International Scientific and Practical Conference “Information and communication technologies: achievements, problems, innovations”, June 14-15, 2018, Novopolotsk, Belarus. – Novopolotsk: Polotsk State University, 2018. – P. 143-145.

2) Yatskou M. M., Grinev V. V., Skakun V. V. Web application for predicting of the alternative splicing events in primary mRNAs of human oncogenes. // Proceedings of the First International Scientific and Practical Conference “Information and communication technologies: achievements, problems, innovations”, June 14-15, 2018, Novopolotsk, Belarus. – Novopolotsk: Polotsk State University, 2018. – P. 23-26.

3) Grinev V. V., Heidenreich O. The fusion oncogenes RUNX1-RUNX1T1 and KMT2A-AFF1 are global regulators of the state of transcriptome in human leukemia cells. // Proceedings of the International Symposium on Genomics, November 21-23, 2017, Minsk, Republic of Belarus. – Minsk: Institute of Genetics and Cytology, 2017. – P. 64-65.

4) Ilyushonak I. M., Gunko E. P., Antonovich M. L., Yatskou M. M., Skakun V. V., Grinev V. V. Study of RNA splicing patterns of the human RUNX1-RUNX1T1 fusion oncogene by the methods of data mining and next-generation sequencing. // Proceedings of the International Symposium on Genomics, November 21-23, 2017, Minsk, Republic of Belarus. – Minsk: Institute of Genetics and Cytology, 2017. – P. 92-93.

5) Artanova D. P., Yatskou M. M., Grinev V. V. Software implementation of human transcriptome assembly. // Proceedings of the International Scientific and Practical Conference “Complex Problems of Technosphere Security”, October 26-28, 2017, Voronezh, Russia. – Voronezh: Voronezh State Technical University, 2017. – P. 224-227.

6) Volkov A. V., Yatskou M. M., Grinev V. V. Development of the simulation model and the study of algorithms for automatic selection of the human exons features. // Proceedings of the International Scientific Conference “Information Technologies and Systems 2017 (ITS 2017)”, October 25, 2017, Minsk, Republic of Belarus. – Minsk: BSUIR, 2017. – P. 228-229.

7) Antonovich M. L., Yatskou M. M., Grinev V. V., Skakun V. V. Investigation of the algorithms of cluster analysis for predicting of alternative splicing events in primary mRNAs of the human RUNX1-RUNX1T1 fusion oncogene. // Proceedings of the International Scientific Congress on Computer Science “Information Systems and Technologies”, October 24-27, 2016, Minsk, Republic of Belarus.

8) Grinev V. V., Heidenreich O. RUNX1-RUNX1T1 fusion oncogene is indirect regulator of the alternative splicing in human leukemia cells. // Third International Scientific Conference “Genetics and Biotechnology in XXI century: challenges, achievements and prospects», November 23-25, 2016, Minsk, Republic of Belarus.

9) Grinev V. V., Ilyushonak I. M., Nakjang S., Bonifer C., Heidenreich O. Detection of the differential splicing events in transcriptome of human cells using next-generation sequencing. // Proceedings of the International Scientific Congress on Computer Science “Information Systems and Technologies”, October 24-27, 2016, Minsk, Republic of Belarus.

10) Grinev V. V., Ilyushonak I. M., Nazarov P. V., Vallar L., Heidenreich O. Identification of the power-law core in human transcriptome. // Proceedings of the International Scientific Congress on Computer Science “Information Systems and Technologies”, October 24-27, 2016, Minsk, Republic of Belarus.

11) Gunko E. P., Yatskou M. M., Grinev V. V., Skakun V. V. Investigation of the applicability of association rule algorithms for validation of exon graph-predicted variants of the oncogenic mRNAs. // Proceedings of the International Scientific Congress on Computer Science “Information Systems and Technologies”, October 24-27, 2016, Minsk, Republic of Belarus.

12) Ilyushonak I. M., Grinev V. V. Structural and functional characterization of the human fusion oncogene RUNX1-RUNX1T1 with bioinformatics approaches. // Proceedings of the International Scientific Congress on Computer Science “Information Systems and Technologies”, October 24-27, 2016, Minsk, Republic of Belarus.

13) Ilyushonak I. M., Heidenreich O., Grinev V. V. Reconstruction of the weighed exon graph for the RUNX1-RUNX1T1 fusion oncogene using RNA-Seq data. / Third International Scientific Conference “Genetics and Biotechnology in XXI century: challenges, achievements and prospects», November 23-25, 2016, Minsk, Republic of Belarus.

14) Grinev V. V., Migas A. A., Kirsanava A. D., Mishkova О. А., Siomava N., Ramanouskaya Т. V., Vaitsiankova А. V., Ilyushonak I. M., Nazarov P. V., Vallar L., Aleinikova О. V. Patterns of alternative splicing of RNA products of the human RUNX1/RUNX1T1 fusion oncogene. // Second International Scientific Conference “Genetics and Biotechnology in XXI century: challenges, achievements and prospects», October 13-16, 2015, Minsk, Republic of Belarus.


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