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Биологический факультет БГУ - Кафедра физиологии человека и животных.    

Laboratory of Physiology

Tatyana O. Suhan

Tatyana O. Suhan

Senior Researcher, Ph.D.. A graduate of the Department of Immunology of the International State Ecological University. Thesis "Fundamental Approaches to the development of enzyme immunoassay of pesticides, " performed in the laboratory of Immunology, Bach Institute, Russian Academy of Sciences. The theme of Ph.D. thesis - "Effect of histone deacetylase inhibitors on the initial stages of angiogenesis.

From May 2002 to February 2005 worked as a researcher in the interdisciplinary laboratory of the Institute of Virology, Goethe University (Frankfurt am Main, Germany). From March 2005 she works in the laboratory of thermoregulationion.

Research interests: Investigation of molecular mechanisms of antiangiogenic activity of histone deacetylase inhibitors; PHOTOPROTECTIVE study the properties of polyphenols from UV-induced cell damage. He has 25 scientific publications.

Key publications:

1. Chemoresistance acquisition induces a global shift of expression of angiogenesis associated genes and increased pro-angiogenic activity in neuroblastoma cells / Michaelis M., Klassert D., Hinsch N., Barth S., Suhan T., Mayer B., Breitling R., Doerr HW., Cinatl Jr., Cinatl J. // Molecular cancer – 2009. – Vol. 8. [ahead of print].
(PubMed) (Pdf - 1024 Kb)

2. Plant Polyphenols against UV-C-Induced Cellular Death / Kostyuk V, Potapovich A, Suhan T, Pastore S, De Luca C, Pressi G, Dal Toso R, Korkina L. // Planta Med. – 2008. – № 74. – Р. 509–514.

3. Ribavirin inhibits angiogenesis by tetrahydrobiopterin depletion / Michaelis M., Suhan T., Michaelis R., Schmidt H., Mohamed A., Doerr H.W., Cinatl J. // The FASEB Journal. – 2007. – Vol. 21. – P. 81-87.
(PubMed) (Pdf - 840 Kb)

4. Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cells / Michaelis M, Suhan T, Michaelis UR, Beek K, Rothweiler F, Tausch L, Werz O, Eikel D, Zornig M, Nau H, Fleming I, Doerr HW, Cinatl J. // Cell Death Differ. – 2006. – Vol. 13,№ 3. – P. 446 – 553.
(PubMed) (Pdf - 175 Kb)

5. Increased replication of human cytomegalovirus in retinal pigment epithelial cells by valproic Acid depends on histone deacetylase inhibition / Michaelis M, Suhan T, Reinisch A, Reisenauer A, Fleckenstein C, Eikel D, Gumbel H, Doerr HW, Nau H, Cinatl J Jr. // Invest. Ophthalmol. Vis. Sci. – 2005. – Vol. 46, № 9. – P. 3451–3457.
(PubMed) (Pdf - 292 Kb)

6. Multimutated herpes simplex virus g207 is a potent inhibitor of angiogenesis / Cinatl J Jr, Michaelis M, Driever PH, Cinatl J, Hrabeta J, Suhan T, Doerr HW, Vogel JU. // Neoplasia. – 2004. – Vol. 6, № 6. – P. 725–35.
(PubMed) (Pdf - 2,2 Мб)

7. Valproic acid and interferon-alpha synergistically inhibit neuroblastoma cell growth in vitro and in vivo / Michaelis M, Suhan T, Cinatl J, Driever PH, Cinatl J Jr. // Int. J. Oncol. – 2004. – Vol. 25, № 6. – P. 1795 – 1799.

8. Valproic acid inhibits angiogenesis in vitro and in vivo / Michaelis M, Michaelis UR, Fleming I, Suhan T, Cinatl J, Blaheta RA, Hoffmann K, Kotchetkov R, Busse R, Nau H, Cinatl J Jr. // Mol. Pharmacol. – 2004. – Vol. 65, № 3. – P. 5207.
(PubMed) (Pdf - 600 Kb)

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